Yasuda Kazushi, Ohki Shigeru, Seguchi Masashi
Department of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Am J Perinatol. 2004 Apr;21(3):131-4. doi: 10.1055/s-2004-823771.
We reconstructed of the aortic arches of two unrelated boys, who were the smaller twin in monochorionic pregnancies, because they had coarctation of the aorta (CoA). They both had hypospadias. The co-twins, the larger twins, had neither CoA nor hypospadias. Although CoA and hypospadias both have been associated separately with monozygotic pregnancy, this is the first report of CoA and hypospadias occurring together. These cases indicate that epigenetic factors such as unbalanced fetal circulation in monochorionic pregnancy may be involved in co-occurrence of CoA and hypospadias.
我们对两名无血缘关系的男孩的主动脉弓进行了重建，他们是单绒毛膜双胎妊娠中较小的胎儿，因为他们患有主动脉缩窄（CoA）。他们都患有尿道下裂。双胎中的另一个胎儿，即较大的胎儿，既没有主动脉缩窄也没有尿道下裂。虽然主动脉缩窄和尿道下裂都分别与单卵双胎妊娠有关，但这是主动脉缩窄和尿道下裂同时出现的首例报告。这些病例表明，单绒毛膜妊娠中胎儿循环不平衡等表观遗传因素可能与主动脉缩窄和尿道下裂的同时出现有关。
