用静脉注射全氟碳乳剂治疗猪减压病。

Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion.

作者信息

Dromsky David M, Spiess Bruce D, Fahlman Andreas

机构信息

Naval Medical Research Center, Bethesda, MD, USA.

出版信息

Aviat Space Environ Med. 2004 Apr;75(4):301-5.

PMID:15086118

Abstract

BACKGROUND

We examined an adjunctive treatment for severe decompression sickness (DCS) to be used when hyperbaric treatment is delayed or unavailable.

HYPOTHESIS

It has been hypothesized that intravenous perfluorocarbon (PFC) emulsion combined with 100% inspired O2 would improve the outcome in severe DCS.

METHODS

Swine (n = 45) were compressed to 4.9 ATA on air for 22 h and brought directly to 1 ATA at 0.9 ATA min(-1). The animals were then randomized to three groups. The first group breathed ambient air, the second group breathed 100% O2, and a third group received 6 ml x kg(-1) of perflubron emulsion (Oxygent) intravenously and breathed 100% O2. Outcomes of neurological and cardiopulmonary DCS and death were recorded.

RESULTS

Animals that received PFC emulsion sustained less DCS (p < 0.01) than the other groups (53% vs. 93%). No animals in the PFC group sustained neurological DCS, which was present in 69% of the subjects in the other two groups.

CONCLUSION

O2 breathing postdive did not significantly reduce morbidity or mortality in this model. Postdive treatment with PFC emulsion and 100% O2 decreased the incidence of DCS after nonstop decompression from saturation.

摘要

背景

我们研究了一种在高压治疗延迟或无法进行时用于治疗严重减压病（DCS）的辅助疗法。

假设

据推测，静脉注射全氟碳（PFC）乳剂联合吸入100%氧气可改善严重DCS的治疗效果。

方法

将45头猪在空气中压缩至4.9ATA，持续22小时，然后以0.9ATA/min（-1）的速度直接降至1ATA。然后将动物随机分为三组。第一组呼吸环境空气，第二组呼吸100%氧气，第三组静脉注射6ml/kg（-1）的全氟溴烷乳剂（Oxygent）并呼吸100%氧气。记录神经和心肺DCS的结果以及死亡情况。