Zhang Rong-Jia, Liu Kan, Kang Zhi-Min, Fan Dan-Feng, Ni Xiao-Xiao, Liu Yun, Lian Qing-Lin, Sun Xue-Jun, Tao Heng-Yi, Xu Wei-Gang
Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China.
Undersea Hyperb Med. 2011 Sep-Oct;38(5):335-43.
The spinal cord is one of the most commonly affected sites in decompression sickness (DCS). Alternative methods have long been sought to protect against DCS spinal cord dysfunction, especially when hyperbaric treatment is unavailable. Use of perfluorocarbon (PFC) emulsion with or without oxygen breathing has shown survival benefits in DCS animal models. The effectiveness of intravenous PFC emulsion with oxygen breathing on spinal cord function was studied. Somatosensory-evoked potentials (SSEPs) and histologic examination were chosen to serve as measures. After fast decompression (203 kPa/minute) from 709 kPa (for 60 minutes), male Sprague-Dawley rats randomly received: 1) air and saline; 2) oxygen (O2) and saline; 3) O2 and PFC emulsion. The incidence and average number of abnormal SSEP waves in survival animals that received O2 and PFC emulsion were significantly reduced (P < 0.05). Foci of demyelination, necrosis and round non-staining defects in white matter regions of the spinal cord could be found in severe DCS rats. We concluded that administration of PFC emulsion combined with oxygen breathing was beneficial for DCS spinal conductive dysfunction in rats.
脊髓是减压病（DCS）中最常受影响的部位之一。长期以来，人们一直在寻找其他方法来预防DCS脊髓功能障碍，尤其是在无法进行高压治疗的情况下。在DCS动物模型中，使用全氟碳（PFC）乳剂加或不加吸氧已显示出对生存有益。研究了静脉注射PFC乳剂并吸氧对脊髓功能的有效性。选择体感诱发电位（SSEP）和组织学检查作为测量指标。雄性Sprague-Dawley大鼠从709 kPa（持续60分钟）快速减压（203 kPa/分钟）后，随机接受：1）空气和生理盐水；2）氧气（O2）和生理盐水；3）O2和PFC乳剂。接受O2和PFC乳剂的存活动物中SSEP波异常的发生率和平均数量显著降低（P<0.05）。在严重DCS大鼠的脊髓白质区域可发现脱髓鞘、坏死灶和圆形无染色缺陷。我们得出结论，PFC乳剂联合吸氧对大鼠DCS脊髓传导功能障碍有益。
