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腹侧和背侧纹状体在工具性条件反射中的不同作用。

Dissociable roles of ventral and dorsal striatum in instrumental conditioning.

作者信息

O'Doherty John, Dayan Peter, Schultz Johannes, Deichmann Ralf, Friston Karl, Dolan Raymond J

机构信息

Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK.

出版信息

Science. 2004 Apr 16;304(5669):452-4. doi: 10.1126/science.1094285.

DOI:10.1126/science.1094285
PMID:15087550
Abstract

Instrumental conditioning studies how animals and humans choose actions appropriate to the affective structure of an environment. According to recent reinforcement learning models, two distinct components are involved: a "critic," which learns to predict future reward, and an "actor," which maintains information about the rewarding outcomes of actions to enable better ones to be chosen more frequently. We scanned human participants with functional magnetic resonance imaging while they engaged in instrumental conditioning. Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor.

摘要

工具性条件作用研究动物和人类如何选择适合环境情感结构的行为。根据最近的强化学习模型,涉及两个不同的成分:一个“评判者”,它学习预测未来的奖励;一个“行动者”,它保存有关行为奖励结果的信息,以便更频繁地选择更好的行为。我们在人类参与者进行工具性条件作用时用功能磁共振成像对他们进行扫描。我们的结果表明腹侧纹状体和背侧纹状体的作用部分可分离,前者对应于评判者,后者对应于行动者。

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