Nicoli S, Amoretti V, Colombo P, Santi P
Dipartimento Farmaceutico, Parco Area delle Scienze 17/A, IT-43100 Parma, Italy.
Skin Pharmacol Physiol. 2004 May-Jun;17(3):119-23. doi: 10.1159/000077237.
The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were studied. The obtained fluxes were compared with those shown by commercial formulations. The results obtained indicate that the bioadhesive film gave rise to a higher transdermal permeation compared to a commercial gel and to a saturated solution of caffeine in water. Additionally, the film did not present the typical time lag of solution and gel. Another peculiar feature of the film is that the percentage of permeated active substance is much higher than that obtained from commercial formulations. Finally, it was possible to modulate caffeine permeation from the film by adding different enhancers/solvents.
这项工作的目的是在体外研究咖啡因从一种新型生物粘附膜透过兔耳皮肤屏障的透皮渗透情况情况。研究了膜组成和制剂中渗透促进剂的存在对其的影响。将获得的通量与市售制剂的通量进行比较。所得结果表明，与市售凝胶和咖啡因在水中的饱和溶液相比，生物粘附膜产生了更高的透皮渗透率。此外，该膜没有呈现出溶液和凝胶典型的时滞。该膜的另一个独特特征是渗透活性物质的百分比远高于市售制剂。最后，通过添加不同的促进剂/溶剂可以调节咖啡因从膜中的渗透。
