钆喷酸葡胺增强磁共振成像对肝局灶性结节性增生和肝细胞癌的动态强化模式评估

Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging.

作者信息

Savellano Dagmar Högemann, Köstler Herbert, Baus Stefan, Mössinger Meike, Gratz Klaus Friedrich, Weimann Arved, Galanski Michael

机构信息

Abteilung für Diagnostische Radiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

出版信息

Invest Radiol. 2004 May;39(5):305-12. doi: 10.1097/01.rli.0000120372.55482.eb.

DOI:10.1097/01.rli.0000120372.55482.eb

PMID:15087726

Abstract

RATIONALE AND OBJECTIVES

Sequential contrast changes of mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance imaging (MRI) were evaluated in the differentiation of focal nodular hyperplasias (FNH) and hepatocellular carcinomas (HCC).

METHODS

Patients with FNH (n = 16) or HCC (n = 12) underwent MRI: T2-weighted fast spin echo before and T1-weighted gradient echo before and 1, 4, 14, and 22 hours after 5 micromol/kg Mn-DPDP. Homogeneity of enhancement and delineation of fibrous scars of FNHs were assessed qualitatively. Lesion-to-liver contrast changes of FNHs and HCCs were compared quantitatively (Mann-Whitney U).

RESULTS

Mn-DPDP improved detection of characteristic scars of FNHs from 50% before to 90% after contrast agent. Apart from fibrous tissue enhancement of FNHs was mostly homogeneous (90%). Time-dependent contrast changes were up to 20 times higher (after 4 hours) for FNHs than HCCs (P < 0.0001).

CONCLUSIONS

Mn-DPDP-enhanced MRI helps to delineate characteristic morphologic features of FNHs and can provide quantitative data differentiating FNH and HCC.

摘要

原理与目的

评估锰福地匹三钠（Mn-DPDP）增强磁共振成像（MRI）的序列对比变化，以鉴别局灶性结节性增生（FNH）和肝细胞癌（HCC）。

方法

16例FNH患者和12例HCC患者接受MRI检查：在静脉注射5 μmol/kg Mn-DPDP前及注射后1、4、14和22小时分别进行T2加权快速自旋回波序列及T1加权梯度回波序列扫描。定性评估FNH的强化均匀性及纤维瘢痕显示情况。定量比较FNH和HCC的病灶-肝脏对比变化（Mann-Whitney U检验）。