Huang Weining, Xu Huijie, Gao Bo
Department of Otorhinolaryngology, Beijing Hospital, Ministry of Health, Beijing, 100730, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Jan;18(1):14-6.
To investigate the effect and toxicity of intratympanic gentamicin injection therapy for intractable vertigo of Menière's disease.
Thirteen patients diagnosed of unilateral Menière's disease were given gentamicin 0.5 ml (26.7 mg/ml) intratympanically once a week for two weeks. All the patients were followed-up for at least two years. The result was monitored using the criteria set by Chinese Otorhinolaryngological Academy and Editorial Board of Chinese Journal of Otorhinlolaryngology in 1996.
Complete or substantial vertigo control was achieved in 12 patients (92.3%). Two weeks after treatment, the pure tone (0.5 kHz, 1.0 kHz, 2.0 kHz, 3.0 kHz) average hearing threshold had no significant change. 8.0 kHz hearing threshold increased significantly in 3 patients(23.1%). 18-24 months after treatment, the hearing threshold increased significantly in 9 patients respectively. No patient felt improved in tinnitus.
Intratympanic gentamicin injection is a simple and cost-effective means for controlling intractable vertigo spelling of Menière's disease, but it also has some toxic effect to hearing.
探讨鼓室内注射庆大霉素治疗梅尼埃病顽固性眩晕的疗效及毒性。
13例单侧梅尼埃病患者每周鼓室内注射庆大霉素0.5 ml（26.7 mg/ml），共2周。所有患者至少随访2年。结果按照中华耳鼻咽喉科学会、中华耳鼻咽喉科杂志编辑委员会1996年制定的标准进行判定。
12例患者（92.3%）眩晕完全或基本得到控制。治疗2周后，纯音（0.5 kHz、1.0 kHz、2.0 kHz、3.0 kHz）平均听阈无明显变化。3例患者（23.1%）8.0 kHz听阈显著升高。治疗18 - 24个月后，9例患者听阈分别显著升高。耳鸣症状无患者感觉改善。
鼓室内注射庆大霉素是控制梅尼埃病顽固性眩晕的一种简单且经济有效的方法，但对听力也有一定毒性作用。
