Dorababu M, Prabha T, Priyambada S, Agrawal V K, Aryya N C, Goel R K
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
Indian J Exp Biol. 2004 Apr;42(4):389-97.
Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g). Ulcer healing activity was studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicated that in both, normal and NIDDM rats, B. monniera extract (BME, 20-100 mg/kg) did not show any significant effect on blood glucose level, while A. indica (AIE, 250-1000 mg/kg) significantly decreased it. However, both BME (50 mg/kg) and AIE (500 mg/kg) showed significant anti-ulcer and ulcer-healing activities in normal and NIDDM rats. Further, the present results also indicated that the ulcer protective effects of BME was more pronounced in non-diabetic, while that of AIE was more in NIDDM rats. The anti-ulcer and ulcer-healing activities of BME and AIE may be due to their effects on various mucosal offensive and defensive factors, and correction of blood sugar level by AIE may help to have more ulcer protective effect in NIDDM rats.
通过各种物理（2小时冷束缚应激和4小时幽门结扎）和化学试剂（乙醇，1ml/200g，口服，提前1小时；阿司匹林，200mg/kg，口服，4小时）在正常/非胰岛素依赖型糖尿病（NIDDM）大鼠中诱导胃溃疡，通过半胱胺（40mg/200g）诱导十二指肠溃疡。在由乙酸（50%）和盐酸（0.6M）诱导的胃溃疡中研究溃疡愈合活性。结果表明，在正常和NIDDM大鼠中，印度薄荷提取物（BME，20-100mg/kg）对血糖水平均未显示出任何显著影响，而印度楝提取物（AIE，250-1000mg/kg）显著降低了血糖水平。然而，BME（50mg/kg）和AIE（500mg/kg）在正常和NIDDM大鼠中均显示出显著的抗溃疡和溃疡愈合活性。此外，目前的结果还表明，BME的溃疡保护作用在非糖尿病大鼠中更为明显，而AIE在NIDDM大鼠中更为明显。BME和AIE的抗溃疡和溃疡愈合活性可能归因于它们对各种黏膜攻击和防御因子的作用，并且AIE对血糖水平的调节可能有助于在NIDDM大鼠中产生更强的溃疡保护作用。
Zotero 插件