Wakisaka S, Sasaki Y, Ichikawa H, Matsuo S
First Department of Oral Anatomy, Osaka University Faculty of Dentistry, Japan.
Proc Finn Dent Soc. 1992;88 Suppl 1:551-5.
An immunohistochemical study was made of the temporal changes in the expression of the c-fos oncogene protein in the spinal trigeminal nucleus complex (STNC) after three different types of dental injury. One hour after tooth extraction or pulp exposure, c-fos neurons appeared in the ipsilateral subnucleus caudalis, but there were very few c-fos neurons in the ipsilateral subnuclei oralis and interpolaris, and in the trigeminal main sensory nucleus and contralateral STNC. The great number of c-fos neurons was found 2-4 hours after injury, levels decreased by 8 hours after injury. Twenty-four hours after injury, the number of these neurons in subnucleus caudalis became very small. Shallow cavity preparation, however, did not induce an increase in the number of c-fos neurons at any selected postoperative time in STNC. These results indicate that c-fos neurons appear mainly in subnucleus caudalis very soon after severe dental injury.
对三种不同类型的牙齿损伤后三叉神经脊束核复合体（STNC）中c-fos癌基因蛋白表达的时间变化进行了免疫组织化学研究。拔牙或牙髓暴露1小时后，c-fos神经元出现在同侧尾侧亚核，但同侧口侧亚核、极间亚核、三叉神经主感觉核和对侧STNC中的c-fos神经元很少。损伤后2-4小时发现大量c-fos神经元，损伤后8小时水平下降。损伤后24小时，尾侧亚核中这些神经元的数量变得非常少。然而，浅龋制备在STNC术后任何选定时间均未诱导c-fos神经元数量增加。这些结果表明，严重牙齿损伤后c-fos神经元很快主要出现在尾侧亚核中。
