血液粘度参数与白血病类型的相关性。

Blood viscosity parameter correlation with types of leukemia.

作者信息

Sharma K, Puniyani R R, Bhat S V, Advani S H, Hegde U, Rao S

机构信息

School of Biomedical Engineering, Indian Institute of Technology, Powai, Bombay.

出版信息

Physiol Chem Phys Med NMR. 1992;24(2):159-64.

PMID:1508991

Abstract

We investigated the hemorheological, hematological and biochemical parameters in 30 cases of acute lymphocytic leukemia (ALL), 21 cases of acute myelogenous leukemia (AML) and 30 cases of chronic myelogenous leukemia (CML). The parameters studied include whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR), red cell filterability, hematocrit, platelet count and aggregation, fibrinogen, hemoglobin, leucocyte count, bleeding time and lactate dehydrogenase activity (LDH). In the cases of ALL we observed significant decrease in whole blood viscosity, hemoglobin, hematocrit and platelet count but an increase in plasma viscosity, fibrinogen, bleeding time and LDH activity. In the cases of AML, we observed increase in whole blood viscosity, plasma viscosity, ESR, fibrinogen, leucocyte count, bleeding time and LDH activity but decrease in the hemoglobin, hematocrit and platelet count. In the cases of CML, we observed an increase of whole blood viscosity, plasma viscosity, ESR, fibrinogen elevation but decreases in bleeding time. In all cases, red cell filterability was unaffected.

摘要

我们对30例急性淋巴细胞白血病（ALL）、21例急性髓细胞白血病（AML）和30例慢性髓细胞白血病（CML）患者的血液流变学、血液学和生化参数进行了研究。所研究的参数包括全血粘度、血浆粘度、红细胞沉降率（ESR）、红细胞滤过率、血细胞比容、血小板计数及聚集性、纤维蛋白原、血红蛋白、白细胞计数、出血时间和乳酸脱氢酶活性（LDH）。在ALL患者中，我们观察到全血粘度、血红蛋白、血细胞比容和血小板计数显著降低，但血浆粘度、纤维蛋白原、出血时间和LDH活性升高。在AML患者中，我们观察到全血粘度、血浆粘度、ESR、纤维蛋白原、白细胞计数、出血时间和LDH活性升高，但血红蛋白、血细胞比容和血小板计数降低。在CML患者中，我们观察到全血粘度、血浆粘度、ESR升高，纤维蛋白原升高，但出血时间缩短。在所有病例中，红细胞滤过率均未受影响。