Janousek Jan, Tomek Viktor, Chaloupecky Václav, Gebauer Roman Antonín
Kardiocentrum, University Hospital Motol, V úvalu 84, 150-06 Prague, Czech Republic.
J Cardiovasc Electrophysiol. 2004 Apr;15(4):470-4. doi: 10.1046/j.1540-8167.2004.03481.x.
The etiology of dilated cardiomyopathy associated with congenital complete AV block has not yet been clarified. Two infants with AV block of autoimmune and surgical etiology, respectively, had received a dual-chamber right ventricular-based pacemaker and developed dilated cardiomyopathy with severe septal to left ventricular free-wall dyssynchrony 3.4 (0.9) years later. After 4 weeks of biventricular pacing and spontaneous junctional narrow QRS rhythm, respectively, both children showed significant improvement in left ventricular function along with reverse remodeling. Thus, electromechanical dyssynchrony associated with conventional right-ventricular-based DDD pacing may play a significant role in the development of dilated cardiomyopathy in the young.
与先天性完全性房室传导阻滞相关的扩张型心肌病的病因尚未明确。两名分别患有自身免疫性和手术源性房室传导阻滞的婴儿接受了双腔右心室起搏治疗，3.4（0.9）年后出现了伴有严重室间隔至左心室游离壁不同步的扩张型心肌病。在分别进行了4周的双心室起搏和自发交界性窄QRS波心律后，两名儿童的左心室功能均有显著改善，同时出现了逆向重构。因此，与传统右心室起搏相关的机电不同步可能在年轻人扩张型心肌病的发生中起重要作用。
