Lee M J, Mueller P R, Dawson S L, McLaughlin D T, Kinney T, Hahn P F, Saini S, Gazelle G S
Department of Radiology, Massachusetts General Hospital, Boston.
Radiology. 1992 Sep;184(3):717-20. doi: 10.1148/radiology.184.3.1509055.
Levels of tissue carcinoembryonic antigen (CEA) in 54 abdominal fine-needle biopsy specimens from 50 patients were measured to ascertain the use of tissue CEA levels in diagnosis of malignancy. Biopsy was performed in the following sites: liver (n = 34), retroperitoneum (n = 8), adrenal gland (n = 3), pancreas (n = 2), omentum (n = 2), pelvis (n = 2), spleen (n = 2), and stomach (n = 1). Histologic findings proved malignancy in 39 patients and benign disease in 11 patients. In these 11 patients, the mean levels of tissue CEA were lower than the normal level of serum CEA (3 ng/mL). Tissue CEA levels were higher than serum CEA levels in nine patients with colonic carcinoma and in 12 of 16 patients with noncolonic CEA-secreting malignancies. Four patients with noncolonic CEA-secreting malignancies had tissue CEA levels within the normal range (less than 3 ng/mL). Tissue CEA levels were also normal in 13 patients with various non-CEA-secreting tumors. Tissue CEA levels may prove useful in biopsy of necrotic or cystic lesions and assessment of response to ablative therapy for colon metastases.
检测了50例患者54份腹部细针穿刺活检标本中的组织癌胚抗原（CEA）水平，以确定组织CEA水平在恶性肿瘤诊断中的应用。活检在以下部位进行：肝脏（n = 34）、腹膜后（n = 8）、肾上腺（n = 3）、胰腺（n = 2）、大网膜（n = 2）、骨盆（n = 2）、脾脏（n = 2）和胃（n = 1）。组织学检查结果证实39例患者为恶性肿瘤，11例患者为良性疾病。在这11例患者中，组织CEA的平均水平低于血清CEA的正常水平（3 ng/mL）。9例结肠癌患者和16例非结肠CEA分泌性恶性肿瘤患者中的12例，其组织CEA水平高于血清CEA水平。4例非结肠CEA分泌性恶性肿瘤患者的组织CEA水平在正常范围内（低于3 ng/mL）。13例各种非CEA分泌性肿瘤患者的组织CEA水平也正常。组织CEA水平在坏死或囊性病变的活检以及结肠转移瘤消融治疗反应的评估中可能有用。
