瑞典北部西博滕郡多发性硬化症的临床特征
Clinical characteristics of multiple sclerosis in Västerbotten County in northern Sweden.
作者信息
Sundström P, Svenningsson A, Nyström L, Forsgren L
机构信息
Department of Pharmacology and Clinical Neuroscience, Umeå University Hospital, Umeå, Sweden.
出版信息
J Neurol Neurosurg Psychiatry. 2004 May;75(5):711-6. doi: 10.1136/jnnp.2003.012856.
BACKGROUND
Most clinical data for multiple sclerosis are hospital based-that is, derived from patients referred to clinics specialising in the disease.
OBJECTIVES
To present data derived from two population based multiple sclerosis populations, an incidence cohort and a prevalence population, from Västerbotten County, northern Sweden.
METHODS
The two populations were identified from multiple sources, and case ascertainment was assured through a personal clinical review, including interviews and examination of the patients.
RESULTS
Characteristics at onset for the different clinical subtypes of multiple sclerosis are presented, including the clinical spectrum of the first attack, the anatomical correlation between the first and second attacks, sex distribution, and disability distribution.
CONCLUSIONS
Based on the comparison of present and earlier natural history data, multiple sclerosis appears to be a slightly more benign disease than previously recognised.
背景
大多数多发性硬化症的临床数据是以医院为基础的——也就是说，这些数据来自转诊至专门诊治该疾病的诊所的患者。
目的
呈现来自瑞典北部韦斯特博滕郡基于人群的两个多发性硬化症群体的数据，一个是发病率队列，另一个是患病率群体。
方法
从多个来源识别出这两个群体，并通过个人临床复查确保病例确诊，复查包括对患者的访谈和检查。
结果
展示了多发性硬化症不同临床亚型的发病特征，包括首次发作的临床症状范围、首次发作与第二次发作之间的解剖学关联、性别分布以及残疾分布。
结论
基于当前和早期自然史数据的比较，多发性硬化症似乎比之前认为的病情稍轻。
Zotero 插件