Nappi A, Cuocolo A, Nicolai E, Imbriaco M, Pace L, Salvatore M
Cattedra di Medicina Nucleare, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II.
Radiol Med. 1992 Jul-Aug;84(1-2):132-9.
The recent development of new radionuclide detectors allows noninvasive outpatient monitoring of left ventricular function. This study was aimed at describing a new radionuclide technique useful to monitor cardiac function and at evaluating its potential clinical applications. We studied 14 normal subjects, 30 patients with coronary artery disease and 25 patients with dilated cardiomyopathy. Left ventricular function was continuously monitored in control conditions at rest, during daily physical activity of different intensity (walking on a level surface and climbing stairs), and during bicycle exercise. Left ventricular ejection fraction (EF) variability during recording in control conditions at rest was 0.2 +/- 1.8%. A significant relationship between outpatient EF at rest and conventional equilibrium radionuclide angiography was observed (r = 0.97, n = 69, p less than 0.001). In normal subjects both daily physical activity and exercise stress test induced an increase in heart rate and EF. In patients with coronary artery disease and in patients with dilated cardiomyopathy a heterogeneous EF response was observed during physical activity and exercise stress test. Our results demonstrate that this technique can be used for the ambulatory monitoring of left ventricular function in both normal subjects and patients with different types of cardiomyopathies.
新型放射性核素探测器的最新进展使得对左心室功能进行无创门诊监测成为可能。本研究旨在描述一种用于监测心脏功能的新型放射性核素技术，并评估其潜在的临床应用。我们研究了14名正常受试者、30名冠心病患者和25名扩张型心肌病患者。在静息对照条件下、不同强度的日常体力活动（在水平面上行走和爬楼梯）期间以及自行车运动期间，持续监测左心室功能。静息对照条件下记录期间左心室射血分数（EF）的变异性为0.2±1.8%。观察到静息门诊EF与传统平衡放射性核素血管造影之间存在显著相关性（r = 0.97，n = 69，p < 0.001）。在正常受试者中，日常体力活动和运动应激试验均导致心率和EF增加。在冠心病患者和扩张型心肌病患者中，在体力活动和运动应激试验期间观察到EF反应异质性。我们的结果表明，该技术可用于正常受试者和不同类型心肌病患者左心室功能的动态监测。
