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[反应性星形胶质细胞水平的磷酸化酶和葡萄糖基转移酶。一项组织化学研究]

[Phosphorylase and glucosyltransferases at the level of reactive astrocytes. A histochemical study].

作者信息

Gerebtzoff M A, Brotchi J, Duchesne P Y, Dresse A

出版信息

C R Seances Soc Biol Fil. 1978;172(2):367-73.

PMID:150929
Abstract

Implantation of cobalt powder in the cerebral cortex of rat determines an epileptogenic focus where two types of reactive astrocytes are observed. The first type is mostly represented in the subcortical white matter but it does exist in the cortex around the implant. Phosphorylase and branching enzyme are both very active in these cells which are filled with glycogen. The second type is limited to the cortex and phosphorylase activity leads to an unbranched polysaccharid. These cells correspond to the "activated astrocytes" described by the authors in a previous paper and observed round irritative lesions which, in the cerebral cortex, produce epileptogenic foci.

摘要

将钴粉植入大鼠大脑皮层会形成一个致痫灶,在该致痫灶中可观察到两种反应性星形胶质细胞。第一种主要存在于皮层下白质中,但在植入物周围的皮层中也有存在。磷酸化酶和分支酶在这些充满糖原的细胞中都非常活跃。第二种仅限于皮层,磷酸化酶活性导致形成无分支的多糖。这些细胞与作者在先前论文中描述的“活化星形胶质细胞”相对应,并在大脑皮层中观察到其围绕刺激性病变,这些病变会产生致痫灶。

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