Nilsson Jakob, Spégel Peter, Nilsson Staffan
Technical Analytical Chemistry, Lund Institute of Technology, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 5;804(1):3-12. doi: 10.1016/j.jchromb.2003.12.036.
The research aimed towards the adaptation of molecularly imprinted polymers (MIPs) to the capillary format and the use of these highly selective matrices for capillary electrochromatography (CEC) is reviewed in this article. The MIP is prepared by incorporation of a template molecule into a polymerization protocol. After polymerization and extraction of the template from the resulting polymer a highly selective material with recognition cavities complementary to the template in size, shape and chemical functionality is obtained. MIPs have been used as recognition elements in several different analytical techniques. In combination with CEC a novel separation system with a unique selectivity towards a predetermined target (the template) is achieved. The merge of molecular imprinting technology (MIT) and CEC have introduced several interesting polymer formats, due to the adaptation of the MIP to the miniaturized capillary format. The polymer formats can be classified according to their preparation protocols and appearance into three conceptually different categories, i.e. the monolith, the coating and the nanoparticles. The preparation protocols, characteristics and applications of these formats will be discussed.
本文综述了旨在使分子印迹聚合物（MIPs）适用于毛细管形式，并将这些高选择性基质用于毛细管电色谱（CEC）的研究。MIP是通过将模板分子引入聚合方案中制备的。在聚合以及从所得聚合物中提取模板之后，可获得一种尺寸、形状和化学功能与模板互补的具有识别空穴的高选择性材料。MIPs已在几种不同的分析技术中用作识别元件。与CEC相结合，可实现对预定目标（模板）具有独特选择性的新型分离系统。由于MIP适用于小型化的毛细管形式，分子印迹技术（MIT）与CEC的结合引入了几种有趣的聚合物形式。聚合物形式可根据其制备方案和外观分为三个概念上不同的类别，即整体柱、涂层和纳米颗粒。将讨论这些形式的制备方案、特性和应用。
