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[导管原位癌:将保乳治疗视为标准治疗是否合乎伦理?]

[Ductal in situ carcinoma: is it ethical to consider the breast conserving therapy as a standard?].

作者信息

Barillot I, Cutuli B, Arnould L

机构信息

Département de radiothérapie, centre de lutte contre le cancer Georges-François-Leclerc, 1, rue du Professeur-Marion, 21079 Dijon, France.

出版信息

Cancer Radiother. 2004 Feb;8(1):9-20. doi: 10.1016/j.canrad.2003.09.003.

Abstract

The increasing incidence of DCIS during the past 20 years needs a continuous evaluation of the treatment strategies and a multidisciplinary decision process. The management of the DCIS remains a challenging issue in 2003. Mastectomy should still be considered as the reference treatment which is able to guarantee cure in almost all cases, whereas breast conserving surgery followed by radiation therapy is associated with 7-10% of local recurrence. However, the increasing knowledge of the predictive factors of the local recurrence allows to propose a conservative treatment strategy to a large amount of patients, without negative impact on their prognosis. This review presents the arguments that permit to justify the reasoned choice of the different therapeutic options according to the clinico-pathological situations.

摘要

在过去20年中,导管原位癌(DCIS)发病率不断上升,这就需要持续评估治疗策略并采用多学科决策流程。在2003年,DCIS的管理仍然是一个具有挑战性的问题。乳房切除术仍应被视为能够在几乎所有病例中确保治愈的参考治疗方法,而保乳手术加放射治疗则有7%至10%的局部复发率。然而,对局部复发预测因素的了解日益增加,使得可以向大量患者提出保守治疗策略,且不会对其预后产生负面影响。本综述提出了一些论据,这些论据能够根据临床病理情况为合理选择不同治疗方案提供依据。

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