Chu Chun-Ping, Qiu De-Lai, Kato Kazuo, Kunitake Takato, Watanabe Shoichi, Yu Nan-Shou, Nakazato Masamitsu, Kannan Hiroshi
Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan.
Regul Pept. 2004 Jun 15;119(1-2):53-9. doi: 10.1016/j.regpep.2003.12.007.
Stresscopin (SCP or urocortin III), a member of the corticotropin-releasing factor (CRF) neuropeptide family, is a high-affinity ligand for the type 2 CRF receptor (CRF(2)). When administered peripherally, SCP suppresses food intake, delays gastric emptying and decreases heat-induced edema. Central administration of CRF produces marked hypertension and increased plasma catecholamine. However, the effects of SCP on the cardiovascular system are unknown. Thus, the present study compared the effects of intracerebroventricular (i.c.v.) administration of CRF and SCP on cardiovascular function. Central administration of SCP (0.05 or 0.5 nmol) elicited transient increases in mean arterial blood pressure (MABP) and heart rate (HR), and the higher dose of SCP (0.5 nmol) resulted in increased plasma epinephrine. In contrast, central administration of CRF provoked long-lasting increases in MABP, HR and plasma catecholamine levels (norepinephrine and epinephrine). Intravenously administered CRF and SCP (0.5 nmol) did not elicit significant changes in MABP and HR. Therefore, these data suggest that centrally administered SCP modulates cardiovascular function, likely through the sympatho-adrenal-medullary (SAM) system.
应激肽（SCP或尿皮质素III）是促肾上腺皮质激素释放因子（CRF）神经肽家族的成员，是2型CRF受体（CRF(2)）的高亲和力配体。外周给予SCP可抑制食物摄入、延迟胃排空并减轻热诱导的水肿。中枢给予CRF会导致明显的高血压和血浆儿茶酚胺增加。然而，SCP对心血管系统的影响尚不清楚。因此，本研究比较了脑室内（i.c.v.）给予CRF和SCP对心血管功能的影响。中枢给予SCP（0.05或0.5 nmol）会引起平均动脉血压（MABP）和心率（HR）短暂升高，较高剂量的SCP（0.5 nmol）会导致血浆肾上腺素增加。相比之下，中枢给予CRF会引起MABP、HR和血浆儿茶酚胺水平（去甲肾上腺素和肾上腺素）的持续升高。静脉注射CRF和SCP（0.5 nmol）不会引起MABP和HR的显著变化。因此，这些数据表明，中枢给予的SCP可能通过交感-肾上腺-髓质（SAM）系统调节心血管功能。
