Pfammatter Jean-Pierre, Pavlovic Mladen, Bauersfeld Urs
Division of Pediatric Cardiology, University Children's Hospital Berne, CH 3010 Bern, Switzerland.
Int J Cardiol. 2004 Apr;94(2-3):279-82. doi: 10.1016/j.ijcard.2003.05.023.
The introduction of radiofrequency catheter ablation as a curative treatment option has led to a much better outlook for children with recurrent supraventricular reentrant tachycardias (SVT). This study sought to evaluate the impact of ablation on pharmacologic treatment of SVT.
Two time periods were retrospectively compared with regard to number of episodes of SVT in different age groups, number of acute drug conversions of SVT, chronic antiarrhythmic drug treatments prescribed: in the first period (1989-1994) management of SVT was exclusively pharmacological whereas during the second period (1995-2000) ablation was an option for patients aged 5 years or older.
The study included 88 pediatric patients with recurrent SVT, 40 in the first period, 48 in the latter. Of these, 16 children (all >5 years of age) had an ablation procedure during the second time period. In patients aged >5 years, the number of documented SVT fell from a mean of 3.7/patient to two episodes. The number of acute drug conversions of SVT decreased from a mean of 1.1/patient to 0.2 (p<0.05) during the second period. In the group of children aged >5 years chronic antiarrhythmic treatment was given during a mean of 15 months/patient in period one compared to 4.6 months (p<0.05) in the second period.
In the current era with increasing use of ablation as first-line treatment in older children with recurrent SVT, acute as well as chronic pharmacologic intervention for SVT has become significantly less frequent.
射频导管消融术作为一种治愈性治疗选择的引入,为患有复发性室上性折返性心动过速(SVT)的儿童带来了更好的前景。本研究旨在评估消融术对SVT药物治疗的影响。
回顾性比较两个时间段不同年龄组的SVT发作次数、SVT急性药物转复次数以及开具的慢性抗心律失常药物治疗情况:在第一个时间段(1989 - 1994年),SVT的治疗完全采用药物治疗,而在第二个时间段(1995 - 2000年),5岁及以上的患者可选择消融术。
该研究纳入了88例复发性SVT的儿科患者,第一个时间段40例,第二个时间段48例。其中,16名儿童(均>5岁)在第二个时间段接受了消融手术。在年龄>5岁的患者中,记录到的SVT次数从平均每位患者3.7次降至2次。第二个时间段SVT的急性药物转复次数从平均每位患者1.1次降至0.2次(p<0.05)。在年龄>5岁的儿童组中,第一个时间段平均每位患者接受慢性抗心律失常治疗15个月,而第二个时间段为4.6个月(p<0.05)。
在当前时代,随着消融术越来越多地被用作年长复发性SVT儿童的一线治疗方法,SVT的急性和慢性药物干预显著减少。