Vermeersch Hubert, Loose David, Lahorte Christophe, Mervillie Kris, Dierckx Rudi, Steinmetz Neil, Vanderheyden Jean-Luc, Cuvelier Claude, Slegers Guido, Van de Wiele Christophe
Department of Head and Neck Surgery, University Hospital Ghent, Belgium.
Nucl Med Commun. 2004 Mar;25(3):259-63. doi: 10.1097/00006231-200403000-00008.
In this study, the potential of 99mTc-HYNIC Annexin-V scintigraphy to visualize primary head and neck carcinoma was assessed and compared with computed tomography (CT) findings and histology. Eighteen patients suspected of having primary head and neck carcinoma underwent a spiral CT scan and 99mTc-HYNIC Annexin-V scintigraphy within 1 week of each other, followed by resection of the suspected lesion. Results obtained by CT and scintigraphy were compared vs. histopathology. The diagnosis was primary head and neck carcinoma in 18 patients, accompanied by lymph node involvement in seven patients. 99mTc-HYNIC Annexin-V uptake was identified in five patients on planar images and in 17 patients on tomographic images (single-photon emission computed tomography, SPECT), corresponding to the pathological regions identified by CT. In the remaining patient, CT and 99mTc-HYNIC Annexin-V scintigraphy were false negative. In 11 patients, SPECT and CT scan were concordant, identifying all primary lesions and two sites of lymph node involvement. In the six remaining patients, CT and SPECT accurately identified the primary lesion, but were discordant with regard to the existence of lymph node involvement. In five of six patients, SPECT failed to identify lymph node involvement, whereas CT scan did not. In the remaining patient, CT scan was false positive for lymph node involvement, whereas SPECT was not. In this series, 99mTc-HYNIC Annexin-V allowed for the visualization of all primary head and neck tumours identified by CT scan, but failed to identify most of the sites of lymph node involvement.
在本研究中，评估了99mTc-HYNIC膜联蛋白V闪烁显像用于可视化原发性头颈部癌的潜力，并与计算机断层扫描（CT）结果及组织学进行比较。18例疑似原发性头颈部癌的患者在彼此相隔1周内分别接受了螺旋CT扫描和99mTc-HYNIC膜联蛋白V闪烁显像，随后切除疑似病变。将CT和闪烁显像获得的结果与组织病理学结果进行比较。18例患者的诊断均为原发性头颈部癌，其中7例伴有淋巴结受累。在平面图像上有5例患者、在断层图像（单光子发射计算机断层扫描，SPECT）上有17例患者发现99mTc-HYNIC膜联蛋白V摄取，与CT确定的病理区域相对应。在其余1例患者中，CT和99mTc-HYNIC膜联蛋白V闪烁显像均为假阴性。在11例患者中，SPECT和CT扫描结果一致，均识别出所有原发性病变及2处淋巴结受累部位。在其余6例患者中，CT和SPECT准确识别出原发性病变，但在淋巴结受累情况方面存在不一致。在这6例患者中的5例中，SPECT未识别出淋巴结受累，而CT扫描识别出了。在其余1例患者中，CT扫描对淋巴结受累呈假阳性，而SPECT未呈假阳性。在本系列研究中，99mTc-HYNIC膜联蛋白V能够使CT扫描识别出的所有原发性头颈部肿瘤可视化，但未能识别出大多数淋巴结受累部位。
