Nakai K, Tajima K, Tanigawa N, Matsumoto N, Zen K, Nomura S, Fujimoto M, Kishimoto Y, Amakawa R, Sawada S, Fukuhara S
First Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka, Japan.
Bone Marrow Transplant. 2004 Jun;33(12):1231-3. doi: 10.1038/sj.bmt.1704523.
We treated three patients with steroid-refractory acute graft-versus-host disease (aGVHD) with intra-arterial steroid-injection therapy (IAST). Two patients with gut aGVHD received IAST into both superior and inferior mesenteric arteries, while one patient with liver aGVHD received IAST into the proper hepatic artery. The volume of stools and the bilirubin level improved soon after IAST. Angiography of the superior and inferior mesenteric arteries was performed in the two patients with steroid-refractory gut aGVHD, and identical abnormal findings were obtained. IAST might be an earlier option for steroid-refractory aGVHD.
我们采用动脉内类固醇注射疗法（IAST）治疗了3例对类固醇难治的急性移植物抗宿主病（aGVHD）患者。2例肠道aGVHD患者接受了肠系膜上动脉和肠系膜下动脉的IAST治疗，而1例肝脏aGVHD患者接受了肝固有动脉的IAST治疗。IAST治疗后不久，粪便量和胆红素水平有所改善。对2例类固醇难治性肠道aGVHD患者进行了肠系膜上动脉和肠系膜下动脉造影，获得了相同的异常结果。IAST可能是类固醇难治性aGVHD的一种早期治疗选择。
