Montgomery J M, Zamorano P L, Garner C C
Departmentof Psychiatry and Behavior Sciences, Nancy Friend Pritzker Laboratory, Stanford University, 1200 Welch Rd., Palo Alto, California 94304-5485, USA.
Cell Mol Life Sci. 2004 Apr;61(7-8):911-29. doi: 10.1007/s00018-003-3364-5.
Neuronal morphogenesis, synaptogenesis and synaptic plasticity are fundamental aspects of nervous system development. Much of our current understanding of how each of these processes contributes to the establishment and maintenance of neural circuitry has come from a molecular description of specific classes of key molecules. With regard to synapse assembly and function, a family of membrane-associated guanylate kinase homologs (MAGUKs) have emerged as central organizers of multicomponent protein signaling complexes. In particular MAGUKs appear to play fundamental roles in the transport, anchoring and signaling of specific subclasses of synaptic receptors and ion channels. In this review, we will focus on the role that subfamilies of MAGUKs play during the formation, maintenance and plasticity of the vertebrate central nervous system glutamatergic synapse.
神经元形态发生、突触形成和突触可塑性是神经系统发育的基本方面。目前我们对这些过程如何促进神经回路的建立和维持的许多理解，都来自于对特定类别关键分子的分子描述。关于突触组装和功能，膜相关鸟苷酸激酶同源物（MAGUKs）家族已成为多组分蛋白质信号复合物的核心组织者。特别是，MAGUKs似乎在突触受体和离子通道的特定亚类的运输、锚定和信号传导中发挥着基本作用。在这篇综述中，我们将重点关注MAGUKs亚家族在脊椎动物中枢神经系统谷氨酸能突触的形成、维持和可塑性过程中所起的作用。
