急性T-2毒素中毒时肠系膜肥大细胞脱颗粒

Mesenteric mast cell degranulation in acute T-2 toxin poisoning.

作者信息

Doebler J A, Martin L J, Morse J D, Ballough G P, Strauss J A, Anthony A

机构信息

Neurotoxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground-Edgewood Area, MD 21010.

出版信息

Toxicol Lett. 1992 Aug;62(1):33-8. doi: 10.1016/0378-4274(92)90075-u.

DOI:10.1016/0378-4274(92)90075-u

PMID:1509504

Abstract

T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50, i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.

摘要

通过对肥大细胞颗粒与天青B的异染反应进行细胞光度分析，测定了T-2毒素诱导的大鼠肠系膜肥大细胞颗粒化的变化。腹腔注射T-2毒素（0.5 - 1.5 LD50）后8小时，观察到颗粒减少（异染物质减少）。这些数据表明，肥大细胞激活发生在急性T-2中毒期间，并增加了肥大细胞介质可能导致毒素诱导的心血管衰竭的可能性。