Choi Hyunjung, Lee Jeongho, Shin Hyun-Jung, Lee Byeong-Gon, Chang Ihseop, Hwang Jae-Sung
Skin Research Institute, R and D Center, Amore-Pacific Corp., Kyounggi-do, Korea.
Planta Med. 2004 Apr;70(4):378-80. doi: 10.1055/s-2004-818955.
In this report, we have demonstrated that deoxypodophyllotoxin from Anthriscus sylvestris (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.
在本报告中，我们已证明峨参中的脱氧鬼臼毒素可减少紫外线诱导的棕色豚鼠皮肤色素沉着。将脱氧鬼臼毒素（在丙二醇：乙醇：水=5:3:2中为0.05%）每天两次局部涂抹于棕色豚鼠的背部皮肤，这些豚鼠使用太阳模拟器进行紫外线照射，持续两周。目视检查和Fontana-Masson染色均表明，与赋形剂处理区域相比，脱氧鬼臼毒素减少了皮肤色素沉着和表皮总黑色素，这表明脱氧鬼臼毒素可能适用于治疗色素沉着过度。
