Zimmermann Grégoire, Favrat Bernard, Muller Jacques, Zullino Daniele, Krenz Sonia, Deyras Eliane, Dorogi Frédéric, Zwahlen André, Besson Jacques
Division d'Abus de Substances Département Universitaire de Psychiatrie Adulte Clinique de Cery 1008 Prilly-Lausanne.
Rev Med Suisse Romande. 2003 Feb;123(2):97-9.
Rapid antagonist induction under anesthesia is a method that has been increasingly used to detoxify opiate addicts. These procedures are useful to reduce the duration and the discomfort of withdrawal. However, the high risk and the cost of these methods require randomized clinical trial to evaluate safety and clinical effectiveness. The University Substance Abuse Division of Lausanne and the Intensive Care Unit of the St-Loup Hospital work on a randomized clinical trial comparing anesthesia-assisted versus traditional clonidine detoxification combined with an additional psychosocial week. This paper describes the technique of anesthesia used in our study. Our clinical experience suggests that, integrating this technique in a multidisciplinary network, with a strong emphasis on post-anesthetic follow-up, is a viable and safe option in the treatment of opiate dependence.
麻醉下快速诱导拮抗剂是一种越来越多地用于使阿片类药物成瘾者戒毒的方法。这些程序有助于缩短戒断的持续时间并减轻不适。然而，这些方法的高风险和成本需要通过随机临床试验来评估安全性和临床有效性。洛桑大学药物滥用科和圣卢普医院重症监护室正在进行一项随机临床试验，比较麻醉辅助与传统可乐定戒毒并额外增加一周心理社会治疗的效果。本文描述了我们研究中使用的麻醉技术。我们的临床经验表明，将该技术整合到多学科网络中，并高度重视麻醉后随访，是治疗阿片类药物依赖的一种可行且安全的选择。
