Hrnciar J, Hrnciarová M, Jakubíková K, Okapcová J
Interná klinika Nemocnice F. D. Roosevelta, Banská, Bystrica.
Vnitr Lek. 1992 May;38(5):426-37.
Insulin resistance (prereceptor, receptor, postreceptor) is a complex phenomenon. It penetrates into the clinical picture via hyperinsulinism as impaired glucose tolerance, or NIDDM, as hyperlipoproteinaemia, arterial hypertension and hirsutism in women (syndrome 5H) associated with the polycystic ovary syndrome or the HAIR-AN syndrome. Based on a group of their 480 patients with NIDDM, 108 women with hirsutism, 320 patients with myocardial infarction and the results of the national cardiovascular programme the authors estimate the prevalence of the 5H syndrome as follows: in the general population 5-10%, in patients with arterial hypertension 15-30%, in NDDM 65-90%, in hirsutic women 10-20% and in patients with myocardial infarction 30-50%. These figures could be, however, substantially higher if as the criterion the IRI response was taken or that of C-peptide in OGTT or the results of the hyperinsulinaemic euglycaemic clamp. The clinical 5H syndrome is a phenomenon of latent insulin resistance perceived late by doctors and patients.
胰岛素抵抗（受体前、受体及受体后水平）是一种复杂的现象。它通过高胰岛素血症影响临床表现，如糖耐量受损、非胰岛素依赖型糖尿病（NIDDM），以及高脂血症、动脉高血压和女性多毛症（5H综合征），后者与多囊卵巢综合征或HAIR - AN综合征相关。基于一组480例NIDDM患者、108例多毛症女性、320例心肌梗死患者以及国家心血管项目的结果，作者估计5H综合征的患病率如下：普通人群中为5 - 10%，动脉高血压患者中为15 - 30%，NDDM患者中为65 - 90%，多毛症女性中为10 - 20%，心肌梗死患者中为30 - 50%。然而，如果以胰岛素抵抗指数（IRI）反应、口服葡萄糖耐量试验（OGTT）中C肽的反应或高胰岛素正常血糖钳夹试验的结果作为标准，这些数字可能会高得多。临床5H综合征是一种医生和患者察觉较晚的潜在胰岛素抵抗现象。
