转移性乳腺癌累及玻璃体。
Metastatic breast carcinoma to the vitreous.
作者信息
Zaldivar Renzo A, Michels Mark, Grant Kenneth F, Clark W Lloyd, Grossniklaus Hans E
机构信息
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
出版信息
Retina. 2004 Apr;24(2):226-30. doi: 10.1097/00006982-200404000-00006.
PURPOSE
To evaluate the clinical and pathologic findings in two patients with prior breast carcinoma who underwent diagnostic vitrectomy for vitreous opacities and preretinal membrane.
METHODS
The clinical histories and ophthalmic findings in two patients were reviewed. Vitrectomy specimens from the patients were processed by cytospin and standard tissue techniques, stained with hematoxylin and eosin, and examined immunohistochemically for cytokeratins. The original breast carcinoma specimens were reviewed.
RESULTS
The vitreous in both patients contained malignant cells with cytologic features consistent with metastatic carcinoma. Immunohistochemical stains were positive for cytokeratins in the cells. The cytologic findings in the vitreous cells resembled the primary breast carcinoma.
CONCLUSIONS
Breast carcinoma may metastasize to the vitreous, most likely via the retina. The clinical manifestations include vitreous cell and preretinal membrane.
目的
评估两名曾患乳腺癌的患者因玻璃体混浊和视网膜前膜接受诊断性玻璃体切割术的临床及病理结果。
方法
回顾两名患者的临床病史和眼科检查结果。对患者的玻璃体切除标本采用细胞离心涂片法和标准组织技术进行处理，苏木精-伊红染色，并进行细胞角蛋白免疫组化检查。复查原始乳腺癌标本。
结果
两名患者的玻璃体中均含有具有与转移性癌一致的细胞学特征的恶性细胞。细胞角蛋白免疫组化染色显示细胞呈阳性。玻璃体细胞的细胞学表现与原发性乳腺癌相似。
结论
乳腺癌可能转移至玻璃体，最可能通过视网膜转移。临床表现包括玻璃体细胞和视网膜前膜。
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