Yu Hee-Joon, Ko Joo-Youn, Kwon Hyeok-Man, Kim Jeong-Soo
Department of Dermatology, Guri Hospital, Hanyang University College of Medicine, Guri City, Gyunggi-do, Seoul 471-701, Korea.
J Am Acad Dermatol. 2004 May;50(5 Suppl):S81-3. doi: 10.1016/s0190-9622(03)02797-x.
Linear psoriasis is an uncommon form of psoriasis characterized by the linear distribution of the psoriatic lesions. It usually follows the lines of Blaschko with unilateral involvement. Poro keratotic eccrine ostial and dermal duct (PEODD) nevus is another rare dermatosis that follows Blaschko's line. The pathogenesis of linear psoriasis and PEODD nevus is unclear, but both could be best explained by a specific somatic mutation. Hence, it has been suggested that the mutation responsible for PEODD nevus would constitute a rare but critical psoriasis gene. In the literature, 1 case of linear psoriasis with PEODD nevus was reported, which may support this suggestion. This article describes another case of linear psoriasis and PEODD nevus. A 7-year-old boy had a 4-month history of multiple psoriasiform plaques, arranged in linear distribution, and had congenital linear hyperkeratotic papules and pits on the right side of his trunk and right arm.
线状银屑病是银屑病的一种罕见形式，其特征为银屑病皮损呈线状分布。它通常沿布拉斯科线分布，单侧受累。汗孔角化性小汗腺导管开口和真皮导管（PEODD）痣是另一种沿布拉斯科线分布的罕见皮肤病。线状银屑病和PEODD痣的发病机制尚不清楚，但两者都可以用特定的体细胞突变来最好地解释。因此，有人提出，导致PEODD痣的突变可能是一种罕见但关键的银屑病基因。文献中报道过1例伴有PEODD痣的线状银屑病病例，这可能支持这一观点。本文描述了另一例线状银屑病和PEODD痣病例。一名7岁男孩有4个月的病史，身上有多个呈线状分布的银屑病样斑块，其躯干右侧和右臂有先天性线状角化过度丘疹和凹坑。
