Evans Alun V, Scarisbrick Julia J, Child F J, Acland Katharine M, Whittaker Sean J, Russell-Jones Robin
Skin Tumour Unit, St John's Institute of Dermatology, London, United Kingdom.
J Am Acad Dermatol. 2004 May;50(5):701-5. doi: 10.1016/j.jaad.2003.11.054.
We retrospectively analyzed the first 461 cases entered into our cutaneous lymphoma database and found 285 cases of mycosis fungoides. We also identified 6 cases of malignant melanoma, all of which were found in patients with mycosis fungoides. The crude rate of melanoma in the general population in England, United Kingdom, in 1998 was 8.8/100,000 in men and 11.4/100,000 in women. The incidence of melanoma found in our cohort of patients with mycosis fungoides was far higher, and in 4 of the 6 patients cannot be explained on the basis of prior therapy. The reason for this association is unclear, but this report emphasizes the risk of second malignancies for patients with cutaneous T-cell lymphoma and melanoma.
我们回顾性分析了录入我们皮肤淋巴瘤数据库的前461例病例，发现285例蕈样肉芽肿。我们还识别出6例恶性黑色素瘤，所有这些病例均在蕈样肉芽肿患者中发现。1998年，英国英格兰普通人群中黑色素瘤的粗发病率男性为8.8/100,000，女性为11.4/100,000。在我们的蕈样肉芽肿患者队列中发现的黑色素瘤发病率要高得多，并且6例患者中有4例无法根据先前的治疗来解释。这种关联的原因尚不清楚，但本报告强调了皮肤T细胞淋巴瘤和黑色素瘤患者发生第二原发恶性肿瘤的风险。
