van den Top Marco, Lee Kevin, Whyment Andrew D, Blanks Andrew M, Spanswick David
Department of Biological Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK.
Nat Neurosci. 2004 May;7(5):493-4. doi: 10.1038/nn1226. Epub 2004 Apr 18.
The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.
下丘脑弓状核（ARC）整合并响应饱腹感和饥饿信号，构成了中枢神经对能量平衡扰动做出反应的起源。在此，我们表明，含有神经肽Y（NPY）和刺鼠相关蛋白（AgRP）的大鼠ARC神经元作为条件起搏器，被食欲素激活，并被厌食素瘦素抑制。我们提出了一种神经元特异性信号传导机制，通过该机制，中枢和外周信号参与中枢神经合成代谢驱动。
