Oshima Kenichi, Tsuchiya Kuniaki, Iritani Shuji, Niizato Kazuhiro, Akiyama Haruhiko, Arai Heii, Ikeda Kenji
Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Japan.
No To Shinkei. 2004 Feb;56(2):157-61.
We report an autopsy case of a Japanese man with "progressive supranuclear palsy (PSP)" who showed neither neurological nor psychiatric signs. Although he died by heart failure at the age of 84 years, he had neither neurological nor psychiatric signs throughout the clinical course. Neuropathological examination revealed neuronal loss of the substantia nigra and pallidum. Neurofibrillary tangles were observed in the caudate nucleus, subthalamic nucleus, pallidum, putamen, substantia nigra, locus ceruleus, pontine nucleus, inferior olivary nucleus, and dentate nucleus, compatible with the NINDS pathological diagnosis of PSP reported in 1994. Staining by Gallyas-Braak methods disclosed tuft-shaped astrocytes in the caudate nucleus, putamen, and thalamus. To our knowledge, this is the first report of "PSP" without psychiatric or neurological signs.
我们报告一例日本男性“进行性核上性麻痹（PSP）”尸检病例，该患者未表现出神经或精神症状。尽管他84岁时死于心力衰竭，但在整个临床过程中均未出现神经或精神症状。神经病理学检查显示黑质和苍白球神经元丢失。在尾状核、丘脑底核、苍白球、壳核、黑质、蓝斑、脑桥核、下橄榄核和齿状核中观察到神经原纤维缠结，符合1994年报道的美国国立神经疾病与中风研究所（NINDS）对PSP的病理诊断。Gallyas-Braak方法染色显示尾状核、壳核和丘脑中存在簇状星形胶质细胞。据我们所知，这是首例无精神或神经症状的“PSP”报告。
