Zhang D H, Yano K, Itoh Y, Mitamura R, Suzuki N, Okuno A
Department of Pediatrics, Asahikawa Medical College, Japan.
Acta Paediatr Jpn. 1992 Jun;34(3):282-9. doi: 10.1111/j.1442-200x.1992.tb00960.x.
The growth hormone (GH) secretory capacities in patients with Turner syndrome aged 5.1-15.9 years and those with constitutional short stature (CSS) aged 5.2-14.2 years were evaluated by pharmacological and physiological means. The GH response to hypoglycemia in the patients with Turner syndrome was lower than that in the patients with CSS. However, the GH response to arginine was not significantly different between the two patient groups. For the physiological test, the integrated concentration of GH (ICGH), the number of episodic peaks and their mean height were evaluated using blood obtained from the patients every 20 minutes for a period of 24 hours. The ICGH and the mean height of the episodic peaks in the patients with Turner syndrome were significantly lower than those in the CSS patients during the night but not during the day. Negative correlation between the bone age and the night-time values of ICGH was observed in the patients with Turner syndrome. Such correlation was not observed in the CSS patients. The patients with CSS showed a significant day-night difference in the ICGH and the mean height of the episodic peaks, but the patients with Turner syndrome did not show any significant day-night difference in either the ICGH or the mean height of episodic peaks. In conclusion, the GH secretory capacity in patients with Turner syndrome is lower than that in CSS patients.
采用药理学和生理学方法评估了年龄在5.1 - 15.9岁的特纳综合征患者以及年龄在5.2 - 14.2岁的体质性矮小症（CSS）患者的生长激素（GH）分泌能力。特纳综合征患者对低血糖的GH反应低于CSS患者。然而，两组患者对精氨酸的GH反应无显著差异。对于生理学测试，通过每20分钟从患者采集一次血样，持续24小时，来评估GH的整合浓度（ICGH）、发作峰次数及其平均高度。特纳综合征患者的ICGH和发作峰的平均高度在夜间显著低于CSS患者，但白天无此差异。在特纳综合征患者中观察到骨龄与夜间ICGH值呈负相关。CSS患者未观察到这种相关性。CSS患者的ICGH和发作峰的平均高度存在显著的昼夜差异，但特纳综合征患者的ICGH或发作峰的平均高度均未显示出任何显著的昼夜差异。总之，特纳综合征患者的GH分泌能力低于CSS患者。
