果蝇及其近缘物种中，甘油磷酸脱氢酶（Gpdh）基因座非编码区保守的（CT）n.（GA）n重复序列是GAGA因子的结合位点。

Conserved (CT)n.(GA)n repeats in the non-coding regions at the Gpdh locus are binding sites for the GAGA factor in drosophila melanogaster and its sibling species.

作者信息

Tchoubrieva E B, Gibson J B

机构信息

Molecular Genetics and Evolution Group, Research School of Biological Sciences, The Australian National University, P.O. Box 475, Canberra, ACT 2601, Australia.

出版信息

Genetica. 2004 May;121(1):55-63. doi: 10.1023/b:gene.0000019922.36436.3c.

DOI:10.1023/b:gene.0000019922.36436.3c

PMID:15098737

Abstract

The (CT)n.(GA)n rich sequences in the upstream and 5' intron enhancer regions of the sn-glycerol-3-phosphate dehydrogenase (Gpdh) gene in Drosophila melanogaster, its sibling and distantly related species are conserved in their position and in the number of repeats. Using in vitro DNA-footprint analyses we show that the GAGA factor binds to these multiple closely spaced and overlapping conserved (CT)n.(GA)n repeats in D. melanogaster and D. erecta.

摘要

在黑腹果蝇、其近缘种和远缘种中，甘油-3-磷酸脱氢酶（Gpdh）基因上游和5'内含子增强子区域富含（CT）n.（GA）n的序列在其位置和重复次数上是保守的。通过体外DNA足迹分析，我们发现GAGA因子与黑腹果蝇和 erecta果蝇中这些多个紧密间隔且重叠的保守（CT）n.（GA）n重复序列结合。