Alexandre Guy P J
Department of Renal and Pancreatic Transplantation at the University Clinics St Luc, University of Louvain, and Interdisciplinary Center for Research in Xenotransplantation (CIREX), University of Liège, Liège, Brussels.
Xenotransplantation. 2004 May;11(3):233-6. doi: 10.1111/j.1399-3089.2004.00105.x.
The development (in 1981) of a protocol for successful renal allotransplantation across ABO barriers is outlined. From this experience, the concept of "adaptation", subsequently termed "accommodation", was defined. It was then hypothesized that a similar approach might allow pig-to-human organ xenotransplantation. This hypothesis was explored in the pig-to-baboon renal transplantation model, with graft survival for a maximum of 23 days. Rejection episodes were temporarily reversed, providing encouragement that discordant xenotransplantation would one day prove successful. Finally, the preparation of the thymokidney, developed as a means of inducing xenotolerance, is briefly reviewed.
概述了（1981年）成功进行ABO血型不相容肾移植的方案的发展历程。基于这一经验，定义了“适应”的概念，随后将其称为“调节”。当时推测，类似的方法可能会使猪到人的器官异种移植成为可能。这一推测在猪到狒狒的肾移植模型中进行了探索，移植肾存活时间最长为23天。排斥反应暂时得到逆转，这为异种移植终有一天会成功提供了鼓舞。最后，简要回顾了作为诱导异种耐受手段而开发的胸腺肾的制备方法。
