Hawkins K A, McGlashan T H, Quinlan D, Miller T J, Perkins D O, Zipursky R B, Addington J, Woods S W
Room 530, CMHC, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA.
Schizophr Res. 2004 Jun 1;68(2-3):339-47. doi: 10.1016/S0920-9964(03)00053-7.
Data from the Scale of Prodromal Symptoms (SOPS) [Early Intervention in Psychotic Disorders, pp. 135-150] on 94 hitherto never-psychotic individuals were entered into a principal components analysis, revealing six components with an eigenvalue greater than 1.0. Based upon scree-plot analysis, further extractions were limited to three, then two, factors. Varimax rotation of the three-component extraction revealed factors with reasonable congruence with a priori content areas. All symptoms labeled as negative in the SOPS loaded on one factor, and four of five symptoms labeled as positive loaded on another. The remaining positive symptom, conceptual disorganization, has been found not to load with other positive-labeled symptoms in studies of schizophrenia using applicable instruments. All symptoms labeled as "general" in the SOPS loaded on a third factor, which appears to reflect the nonspecific psychological distress that might be expected in psychosis-naïve individuals experiencing the preliminary stages of a serious psychiatric disorder. The independence of this component from the positive and negative symptom factors suggests that the structure obtained suggests a clinical continuity between the at-risk presentations seen in this sample and established schizophrenia.
来自前驱症状量表(SOPS)[《精神病性障碍的早期干预》,第135 - 150页]针对94名此前从未患过精神病的个体的数据被纳入主成分分析,结果显示有六个特征值大于1.0的成分。基于碎石图分析,进一步提取限于三个,然后是两个因素。对三个成分提取进行方差最大化旋转后,发现各因素与先验内容领域具有合理的一致性。SOPS中所有标记为阴性的症状都加载在一个因素上,五个标记为阳性的症状中有四个加载在另一个因素上。其余的阳性症状,即概念紊乱,在使用适用工具对精神分裂症的研究中被发现不与其他标记为阳性的症状加载在一起。SOPS中所有标记为“一般”的症状都加载在第三个因素上,这似乎反映了在经历严重精神障碍初始阶段的未患过精神病的个体中可能预期的非特异性心理困扰。该成分与阳性和阴性症状因素的独立性表明,所获得的结构表明该样本中所见的高危表现与已确诊的精神分裂症之间存在临床连续性。