Toomey R, Faraone S V, Simpson J C, Tsuang M T
Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center and Brockton/West Roxbury Veterans Affairs Medical Center, Brockton 02301, USA.
J Nerv Ment Dis. 1998 Aug;186(8):470-6. doi: 10.1097/00005053-199808000-00004.
We compared the factor structure of positive and negative symptoms in schizophrenia (N = 214), major depression (N = 97), and bipolar disorder (N = 58) to determine whether schizophrenia factors would generalize to mood disorders. A study of schizophrenia and mood disorders identified patients whose symptoms were evaluated with the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. We conducted principal component analyses with orthogonal rotation on the global ratings. The factor structure replicated earlier findings of three factors (negative, positive, and disorganization) in groups with schizophrenia, combined mood disorders, and psychotic symptoms, regardless of diagnosis. An additional negative symptom factor was found in the major depression group. The bipolar group did not have a disorganization factor. Similar symptom factors in schizophrenia and mood disorders suggest a continuity in the major affective and psychotic disorders that appears to reflect the underlying dimension of a psychotic process.
我们比较了精神分裂症（N = 214）、重度抑郁症（N = 97）和双相情感障碍（N = 58）中阳性和阴性症状的因子结构，以确定精神分裂症的因子是否适用于心境障碍。一项关于精神分裂症和心境障碍的研究纳入了使用阴性症状评估量表和阳性症状评估量表对症状进行评估的患者。我们对总体评分进行了正交旋转的主成分分析。无论诊断如何，因子结构在患有精神分裂症、合并心境障碍和精神病性症状的组中重复了先前三个因子（阴性、阳性和紊乱）的研究结果。在重度抑郁症组中发现了一个额外的阴性症状因子。双相情感障碍组没有紊乱因子。精神分裂症和心境障碍中相似的症状因子表明主要情感障碍和精神病性障碍之间存在连续性，这似乎反映了精神病性过程的潜在维度。
