Suzuki Shunichi, Suzuki Yasuo, Ohtsuka Kenji
Department of Ophthalmology, School of Medicine, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan.
Neurosci Res. 2004 May;49(1):39-45. doi: 10.1016/j.neures.2004.01.009.
Results of our previous studies suggest that the circumscribed area in the rostral superior colliculus (SC) of the cat is involved in the control of accommodation. Accommodation is closely linked with vergence eye movements. In this study, we investigated whether or not vergence eye movements are evoked by microstimulation of the rostral SC in the cat. In addition, we studied the effect of chemical inhibition of the rostral SC on visually guided vergence eye movements. This study was conducted on three cats, weighing 2.5-3.5 kg. The animals were trained to carry out visually guided saccade and convergence tasks. Eye movements were measured using search coils placed on both eyes. We recorded eye movements evoked by microstimulation of the rostral SC in the alert cats. Muscimol was injected into the rostral SC, and the effect of SC inactivation on visually guided vergence eye movements was investigated. Convergence eye movements were evoked by low-current stimulation (< 30 microA) of a circumscribed area in the intermediate layers of the rostral SC on one side. Spontaneous saccades were interrupted by the stimulation of the low-threshold area for evoking convergence. Visually guided convergence eye movements were severely diminished by the injection of muscimol into the low-threshold area for evoking convergence of the SC. The rostral SC is related to the control of vergence eye movements as well as accommodation. The rostral SC may be involved in the functional linkage between accommodation, convergence and visual fixation.
我们之前研究的结果表明，猫的 Rostral 上丘（SC）中的限定区域参与了调节控制。调节与双眼会聚眼球运动密切相关。在本研究中，我们调查了猫 Rostral 上丘的微刺激是否会诱发双眼会聚眼球运动。此外，我们研究了 Rostral 上丘的化学抑制对视觉引导的双眼会聚眼球运动的影响。本研究对三只体重为 2.5 - 3.5 千克的猫进行。训练这些动物执行视觉引导的扫视和会聚任务。使用放置在双眼上的搜索线圈测量眼球运动。我们记录了清醒猫 Rostral 上丘微刺激诱发的眼球运动。将蝇蕈醇注射到 Rostral 上丘中，并研究上丘失活对视觉引导的双眼会聚眼球运动的影响。一侧 Rostral 上丘中间层限定区域的低电流刺激（<30 微安）可诱发会聚眼球运动。低阈值区域的刺激会中断自发扫视，该区域用于诱发会聚。将蝇蕈醇注射到上丘诱发会聚的低阈值区域后，视觉引导的会聚眼球运动严重减弱。Rostral 上丘与双眼会聚眼球运动的控制以及调节有关。Rostral 上丘可能参与了调节、会聚和视觉注视之间的功能联系。
