Zhang Aibin, RajanBabu T V
Department of Chemistry, 100 West 18th Avenue, The Ohio State University, Columbus, Ohio 43210, USA.
Org Lett. 2004 Apr 29;6(9):1515-7. doi: 10.1021/ol0495063.
[reaction: see text] C(2)-Symmetric P-(2-X-aryl)-2,5-dialkylphospholanes (X = dioxolan-2-yl or dioxan-2-yl), designed on the basis of a working model for asymmetric induction, are effective ligands for the Ni(II)-catalyzed asymmetric hydrovinylation of styrenes. Excellent yields (>99%), selectivities for the desired 3-arylbutenes (>99%), high S/C ratios (>1200), and ee's (up to 91%) have been realized for a number of prototypical vinylarenes. In the dioxolane series, the selectivity depends on the configuration of the C(4) and C(5)() carbons.
[反应：见正文] 基于不对称诱导工作模型设计的C(2)对称的P-(2-X-芳基)-2,5-二烷基膦烷（X = 二氧戊环-2-基或二氧六环-2-基）是镍(II)催化苯乙烯不对称氢乙烯基化反应的有效配体。对于多种典型的乙烯基芳烃，已实现了优异的产率（>99%）、对所需3-芳基丁烯的选择性（>99%）、高S/C比（>1200）以及对映体过量值（高达91%）。在二氧戊环系列中，选择性取决于C(4)和C(5)（）碳的构型。
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