表达HLA-G1的抗原呈递细胞诱导免疫抑制性CD4+ T细胞。
HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells.
作者信息
LeMaoult Joël, Krawice-Radanne Irène, Dausset Jean, Carosella Edgardo D
机构信息
Service de Recherches en Hémato-Immunologie, Commissariat à L'Energie Atomique Departement de Recherche Medicale-Direction des Sciences du Vivant, Hôpital Saint Louis, 1 Avenue Claude Vellefaux, 75475 Paris 10, France.
出版信息
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7064-9. doi: 10.1073/pnas.0401922101. Epub 2004 Apr 21.
Abstract
We recently reported that HLA-G1-transfected antigen-presenting cells (HLA-G1+ APCs) were capable of inhibiting alloproliferative responses. The aim of the present work was to further study the function and the mechanisms of action of HLA-G1+ APCs. We show here that HLA-G1+ APCs are immunoinhibitory cells that (i) inhibit the proliferation of CD4+ T cells, (ii) shed HLA-G1 molecules that might provide extra, non-antigen-specific, inhibitory or proapoptotic signals, (iii) induce CD4+ T cell anergy, or at least long-term unresponsiveness, and (iv) cause the differentiation of CD4+ T cells into suppressive cells. Thus, HLA-G+ APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance.
摘要
我们最近报道，转染了HLA - G1的抗原呈递细胞（HLA - G1 + APCs）能够抑制同种异体增殖反应。本研究的目的是进一步研究HLA - G1 + APCs的功能及作用机制。我们在此表明，HLA - G1 + APCs是免疫抑制细胞，其能够：（i）抑制CD4 + T细胞的增殖；（ii）释放HLA - G1分子，这些分子可能提供额外的、非抗原特异性的抑制或促凋亡信号；（iii）诱导CD4 + T细胞无能，或至少导致长期无反应性；（iv）使CD4 + T细胞分化为抑制性细胞。因此，HLA - G + APCs可能（i）参与免疫反应的直接抑制，并且（ii）有助于长期有效的免疫逃逸或耐受。
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