调节性T细胞对树突状细胞的耐受性诱导：抑制性受体ILT3和ILT4的关键作用
Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.
作者信息
Chang C C, Ciubotariu R, Manavalan J S, Yuan J, Colovai A I, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N
机构信息
Department of Pathology, Columbia University, New York, NY 10032, USA.
出版信息
Nat Immunol. 2002 Mar;3(3):237-43. doi: 10.1038/ni760. Epub 2002 Jan 28.
Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28(-) alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.
免疫球蛋白样转录物3（ILT3）和ILT4属于由人单核细胞和树突状细胞表达的抑制性受体家族。我们在此表明，CD8 + CD28（-）同种异体抗原特异性T抑制细胞（TS细胞）可诱导单核细胞和树突状细胞上ILT3和ILT4的上调，使这些抗原呈递细胞（APC）具有耐受性。耐受性APC显示共刺激分子表达降低，并在CD4 + T辅助细胞中诱导抗原特异性无反应性。对人类心脏移植受者的研究表明，无排斥反应的患者具有循环TS细胞，其可诱导供体APC中ILT3和ILT4的上调。这些发现证明了免疫调节的重要机制。
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