肺炎链球菌中YycF应答调节蛋白同源物MicA的D59A突变体的结晶及初步晶体学研究
Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae.
作者信息
Riboldi-Tunnicliffe Alan, Trombe Marie Claude, Bent Colin J, Isaacs Neil W, Mitchell Timothy J
机构信息
IBLS, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, Scotland.
出版信息
Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):950-1. doi: 10.1107/S0907444904005712. Epub 2004 Apr 21.
RR02 (MicA) is an essential bacterial protein that belongs to the YycF family of response regulators and consists of two domains: an N-terminal receiver domain and a C-terminal effector domain. Streptococcus pneumoniae RR02 (MicA; residues 2-234) has been crystallized using the sitting-drop vapour-diffusion technique. The crystals belong to space group P2(1), with unit-cell parameters a = 46.46, b = 32.61, c = 63.35 A, beta = 90.01 degrees. X-ray diffraction data have been collected to 1.93 A resolution.
RR02（MicA）是一种必需的细菌蛋白，属于响应调节因子的YycF家族，由两个结构域组成：一个N端接收结构域和一个C端效应结构域。肺炎链球菌RR02（MicA；第2至234位氨基酸残基）已采用坐滴气相扩散技术进行结晶。晶体属于空间群P2(1)，晶胞参数为a = 46.46、b = 32.61、c = 63.35 Å，β = 90.01°。已收集到分辨率为1.93 Å的X射线衍射数据。
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