一种由芳基溴化物简便合成烷基芳基硫醚的一锅法。

A facile one-pot synthesis of alkyl aryl sulfides from aryl bromides.

作者信息

Ham Jungyeob, Yang Inho, Kang Heonjoong

机构信息

Marine Biotechnology Laboratory and Research Institute of Oceanography, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.

出版信息

J Org Chem. 2004 Apr 30;69(9):3236-9. doi: 10.1021/jo049758h.

DOI:10.1021/jo049758h

PMID:15104475

Abstract

A convenient one-pot synthetic method for the formation of alkyl aryl sulfides from various alkyl halides and lithium aryl thiolates that are prepared in situ by direct halogen-lithium exchange is reported. In particular, the method overcomes many of the problems encountered in previous reports; it is very quick, catalyst-free, and does not involve use of unstable aryl thiols.

摘要

报道了一种便捷的一锅合成方法，可由各种卤代烃和通过直接卤锂交换原位制备的芳基硫醇锂生成烷基芳基硫醚。特别地，该方法克服了先前报道中遇到的许多问题；它非常快速、无需催化剂，且不涉及使用不稳定的芳基硫醇。