一种简便的一锅法制备羟基芳基钾盐和（羟烷基）芳基三氟硼酸盐。
A facile one-pot preparation of potassium hydroxyaryl- and (hydroxyalkyl)aryltrifluoroborates.
作者信息
Park Young Hee, Ahn Hong Ryul, Canturk Belgin, Jeon Sang Il, Lee Seokjoon, Kang Heonjoong, Molander Gary A, Ham Jungyeob
机构信息
Korea Institute of Science and Technology, 290 Daejeon-dong, Gangneung 210-340, Korea.
出版信息
Org Lett. 2008 Mar 20;10(6):1215-8. doi: 10.1021/ol800083j. Epub 2008 Feb 23.
Potassium hydroxyaryl- and (hydroxyalkyl)aryltrifluoroborates have been prepared in a simple one-pot process from the corresponding hydroxy-substituted aryl halides in 51-98% yields through an in situ protection of the free hydroxyl group with t-BuLi. Also, we successfully performed a microwave-promoted Suzuki-Miyaura cross-coupling reaction of these substrates with aryl- and alkenyl bromides in the presence of 0.5 mol % of Pd(OAc)2 catalyst without ligands.
通过用叔丁基锂原位保护游离羟基，以简单的一锅法由相应的羟基取代芳基卤化物制备了羟基芳基硼酸酯和（羟烷基）芳基三氟硼酸盐，产率为51-98%。此外，我们在没有配体的0.5 mol% Pd(OAc)₂催化剂存在下，成功地对这些底物与芳基溴化物和烯基溴化物进行了微波促进的铃木-宫浦交叉偶联反应。
Zotero 插件