Morimoto Yasuhiro, Hagihira Satoshi, Koizumi Yumika, Ishida Kazuyoshi, Matsumoto Mishiya, Sakabe Takefumi
Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Minami-Kogushi Ube, Yamaguchi, 755-8505, Japan.
Anesth Analg. 2004 May;98(5):1336-40, table of contents. doi: 10.1213/01.ane.0000105867.17108.b6.
Bispectral index (BIS) integrates various electroencephalographic (EEG) parameters into a single variable. However, the exact algorithm used to synthesize the parameters to BIS values is not known. The relationship between BIS and EEG parameters was evaluated during nitrous oxide/isoflurane anesthesia. Twenty patients scheduled for elective ophthalmic surgery were enrolled in the study. After EEG recording with a BIS monitor (A-1050) was begun, general anesthesia was induced and maintained with 0.5%-2% isoflurane and 66% nitrous oxide. Using software we developed, we continuously recorded BIS, spectral edge frequency 95% (SEF95), and EEG parameters such as relative beta ratio (BetaRatio), relative synchrony of fast and slow wave (SynchFastSlow), and burst suppression ratio. BetaRatio was linearly correlated with BIS (r = 0.90; P < 0.01; n = 253) at BIS more than 60. At a BIS range of 30 to 80, SynchFastSlow (r = 0.60; P < 0.01; n = 3314) and SEF95 (r = 0.75; P < 0.01; n = 3339) were linearly correlated with BIS. The correlation between BIS and SEF95 was significantly better than the correlation between BIS and SynchFastSlow (P < 0.01). At BIS less than 30, the burst suppression ratio was inversely linearly correlated with BIS (r = 0.76; P < 0.01; n = 65). At BIS less than 80, burst-compensated SEF95 was linearly correlated with BIS (r = 0.78; P < 0.01; n = 3404). In the range of BIS from 60 to 100, BIS can be calculated from BetaRatio. At surgical levels of anesthesia, BIS and SynchFastSlow (a parameter derived from bispectral analysis) or burst-compensated SEF95 (derived from power spectral analysis) are well correlated. However, our results show that SynchFastSlow has no advantage over SEF95 in calculation of BIS.
The relationship between bispectral index (BIS) and electroencephalographic parameters was evaluated during nitrous oxide/isoflurane anesthesia. At surgical levels of anesthesia, BIS and the relative synchrony of fast and slow wave (a parameter derived from bispectral analysis) or burst-compensated spectral edge frequency 95% (a parameter derived from power spectral analysis) are well correlated.
脑电双频指数（BIS）将各种脑电图（EEG）参数整合为一个单一变量。然而，用于将这些参数合成BIS值的确切算法尚不清楚。在氧化亚氮/异氟烷麻醉期间评估了BIS与EEG参数之间的关系。20例计划行择期眼科手术的患者纳入本研究。在用BIS监测仪（A - 1050）开始记录EEG后，采用0.5% - 2%异氟烷和66%氧化亚氮诱导并维持全身麻醉。使用我们开发的软件持续记录BIS、频谱边缘频率95%（SEF95）以及诸如相对β比率（BetaRatio）、快慢波相对同步性（SynchFastSlow）和爆发抑制率等EEG参数。当BIS大于60时，BetaRatio与BIS呈线性相关（r = 0.90；P < 0.01；n = 253）。在BIS范围为30至80时，SynchFastSlow（r = 0.60；P < 0.01；n = 3314）和SEF95（r = 0.75；P < 0.01；n = 3339）与BIS呈线性相关。BIS与SEF95之间的相关性显著优于BIS与SynchFastSlow之间的相关性（P < 0.01）。当BIS小于30时，爆发抑制率与BIS呈负线性相关（r = 0.76；P < 0.01；n = 65）。当BIS小于80时，爆发补偿SEF95与BIS呈线性相关（r = 0.78；P < 0.01；n = 3404）。在BIS为60至100的范围内，可根据BetaRatio计算BIS。在手术麻醉水平下，BIS与SynchFastSlow（双谱分析得出的参数）或爆发补偿SEF95（功率谱分析得出的参数）相关性良好。然而，我们的结果表明，在计算BIS方面，SynchFastSlow并不比SEF95有优势。
在氧化亚氮/异氟烷麻醉期间评估了脑电双频指数（BIS）与脑电图参数之间的关系。在手术麻醉水平下，BIS与快慢波相对同步性（双谱分析得出的参数）或爆发补偿频谱边缘频率95%（功率谱分析得出的参数）相关性良好。
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