Wilson Clive G
Department of Pharmaceutical Sciences, University of Strathclyde, Royal College, Strathclyde, Glasgow, Scotland G1 1XW, UK.
Exp Eye Res. 2004 Mar;78(3):737-43. doi: 10.1016/j.exer.2003.10.004.
Introduction of a drug or polymer directly into the conjunctival sac should, in theory, facilitate the maximum level of efficacy. In practice, most material undergoes non-productive loss. The work of David Maurice facilitated a better understanding of drug entry by the study of probes delivered in several formulations, and by the construction of instruments to study probe distribution. This review describes research on the applications of gamma scintigraphy to follow the residence of polymers in the eye and the evaluation of the data to assess potential new materials. Finally, our progress on the construction of an ocular spectrometer to directly follow drug entry following topical administration is described.
理论上，将药物或聚合物直接引入结膜囊应能实现最大程度的疗效。但在实际操作中，大多数物质会发生无效损失。大卫·莫里斯的研究通过对多种制剂中递送的探针进行研究，以及构建用于研究探针分布的仪器，有助于更好地理解药物进入情况。本综述描述了关于应用γ闪烁显像术追踪聚合物在眼内的留存情况以及评估数据以评估潜在新材料的研究。最后，介绍了我们在构建眼用光谱仪以直接追踪局部给药后药物进入情况方面取得的进展。
