Angell Annette, McGuigan Christopher, Garcia Sevillano Luis, Snoeck Robert, Andrei Graciela, De Clercq Erik, Balzarini Jan
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
Bioorg Med Chem Lett. 2004 May 17;14(10):2397-9. doi: 10.1016/j.bmcl.2004.03.029.
Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides.
已合成了带有对烷基苯基侧链的强效且选择性的呋喃嘧啶抗水痘带状疱疹病毒（VZV）核苷家族的噻吩类似物，并测试了它们对水痘带状疱疹病毒（VZV）的抗病毒活性。虽然烷基链类似物对VZV显示出完全的抗病毒活性，但与它们的呋喃母体核苷相比，这些新类似物却没有。
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