McGuigan Christopher, Bidet Olivier, Derudas Marco, Andrei Graciela, Snoeck Robert, Balzarini Jan
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK.
Bioorg Med Chem. 2009 Apr 15;17(8):3025-7. doi: 10.1016/j.bmc.2009.03.022. Epub 2009 Mar 14.
Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3-4 orders of potency.
新型烯基取代的芳基双环呋喃嘧啶已被制备并在体外针对水痘带状疱疹病毒（VZV）进行了评估。对位取代的类似物保留了我们报道的对烷基类似物的纳摩尔效力，而邻位和间位烯基系统的效力则降低了3 - 4个数量级。
