重组人生长激素对肝硬化肝细胞癌肝切除术后残肝的影响。
Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis.
作者信息
Luo Shi-Min, Liang Li-Jian, Lai Jia-Ming
机构信息
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 56 Zhongshan Er Lu, Guangzhou 510080, Guangdong Province, China.
出版信息
World J Gastroenterol. 2004 May 1;10(9):1292-6. doi: 10.3748/wjg.v10.i9.1292.
AIM
To explore the effects of recombinant human growth hormone (rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
METHODS
Twenty-four patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into 2 groups: parenteral nutrition (PN) group (n=12) and rhGH+PN group (n=12). Liver function, blood glucose, AFP, serum prealbumin and transferrin were detected before operation, at post-operative d 1 and d 6. Albumin (ALB) mRNA in liver biopsy specimens was detected by RT-PCR at post-operative d 6. Liver Ki67 immunohistochemical staining was studied.
RESULTS
On post-operative d 6, compared with PN group, the levels of blood glucose, serum prealbumin, transferrin, the expression of hepatic ALB mRNA and liver Ki67 labeling index were higher in rhGH+PN group.
CONCLUSION
rhGH can improve protein synthesis and liver regeneration after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
目的
探讨重组人生长激素（rhGH）对肝硬化肝细胞癌肝切除术后残肝的影响。
方法
将24例行肝切除术的肝细胞癌患者随机分为2组：肠外营养（PN）组（n = 12）和rhGH + PN组（n = 12）。于术前、术后第1天和第6天检测肝功能、血糖、甲胎蛋白、血清前白蛋白和转铁蛋白。术后第6天采用RT-PCR检测肝活检标本中白蛋白（ALB）mRNA。进行肝脏Ki67免疫组织化学染色研究。
结果
术后第6天，与PN组相比，rhGH + PN组血糖、血清前白蛋白、转铁蛋白水平、肝脏ALB mRNA表达及肝脏Ki67标记指数更高。
结论
rhGH可改善肝硬化肝细胞癌肝切除术后的蛋白质合成及肝脏再生。
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