[一氧化碳对器官损伤的保护作用]

[Protective effect of carbon monoxide for organ injury].

作者信息

Nakao Atsunori, Kobayashi Eiji, Tanaka Noriaki, Murase Noriko

机构信息

Thomas E Starzl Tranzplantation Institute, University of Pittsburgh, USA.

出版信息

Nihon Geka Gakkai Zasshi. 2004 Apr;105(4):309-13.

PMID:15112495

Abstract

Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

摘要

血红素加氧酶（HO）将血红素分解为三种产物：一氧化碳（CO）、胆绿素和游离铁。HO-1是HO的诱导形式，已被证明对各种应激具有保护作用。低浓度的CO在几种模拟HO-1作用的疾病模型中已被证明具有保护作用。我们认为，血红素降解的副产物CO可能是有价值的治疗药物。我们综述了HO-1和CO的功能作用及其在临床环境中的潜在应用。