全身热疗与白细胞介素-2联合增强大鼠对肉瘤45的抗肿瘤反应。
Enhancement of antitumor response to sarcoma 45 in rats by combination of whole-body hyperthermia and interleukin-2.
作者信息
Potapnev Michael P, Istomin Yuri P, Ismail-zade Reiman S, Zhavrid Edvard A
机构信息
Research Department, Belarussian Research Center for Pediatric Oncology & Hematology, P.O. Lesnoy, Minsk BE-223052, Belarus.
出版信息
Eksp Onkol. 2004 Mar;26(1):67-70.
AIM
To evaluate the summarized effect of hyperthermia and interleukin-2 (IL-2) administration on antitumor defense in tumor-bearing rats.
METHODS
Nonbred rats after subcutaneous inoculation of sarcoma 45 cells were treated with whole-body hyperthermia (WBH, +42.5 degrees C, 60 min) and interleukin-2 (IL-2, 10,000 U/kg of body weight). Parameters of tumor growth and survival of animals were monitored till day 33 after tumor cell inoculation.
RESULTS
Combined application of WBH and IL-2 at 5th day after tumor cell transplantation resulted in a delay of tumor growth and improvement of survival parameters in comparison with control group or animals that received separate treatment. Therapeutic efficacy of WBH combined with IL-2 was analogous to a single-dose chemotherapy with cyclophosphamide.
CONCLUSION
Combined application of WBH and IL-2 is the useful approach for cancer immunotherapy.
目的
评估热疗和白细胞介素-2（IL-2）给药对荷瘤大鼠抗肿瘤防御的综合作用。
方法
皮下接种肉瘤45细胞后的未育大鼠接受全身热疗（WBH，42.5摄氏度，60分钟）和白细胞介素-2（IL-2，10,000 U/kg体重）治疗。监测动物肿瘤生长参数和生存期直至肿瘤细胞接种后第33天。
结果
与对照组或接受单独治疗的动物相比，肿瘤细胞移植后第5天联合应用WBH和IL-2导致肿瘤生长延迟和生存参数改善。WBH联合IL-2的治疗效果类似于环磷酰胺单剂量化疗。
结论
WBH和IL-2联合应用是癌症免疫治疗的有效方法。
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